A Comprehensive Review on Sustained Release Matrix Drug Delivery System

Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as most likely type prolonged drug release. In order to generate therapeutic activity a protracted duration, maintain stable plasma concentration and sustain rate throughout time. preparations with short half-life high dosage frequency, extended-release is crucial. regulates how quickly released. Retardants such polyglycolic acid, polymethyl methacrylate, hydroxypropyl methylcellulose (HPMC) used. retardant's core contains medication. matrices employed can be mineral-based, hydrophobic, or biodegradable. Drug regulated that made using wet granulation direct compression techniques by use various kinds polymers. from controlled both diffusion- dissolution-controlled process. As result, increase efficacy while reducing frequency administration increasing patient compliance.
 Keywords: Sustained release, Matrix Tablets, HPMC, Retardants, Biodegradable